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Explore PIM2 and MYC research coauthored by members of our leadership team.

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PIM2 / MYCJournal articles & conference abstracts2010—2026

27 publications

Newest first

20263 publications

Abstract excerpt from Why are long-lived plasma cells long-lived?. Authors: Julia Grace Reinke; Christopher Schorr; Kelvin Paul Lee

7 May 2026Journal article

Plasma-cell longevity and MYC metabolism

This review connects CD28–IRF4–MYC signaling with mitochondrial metabolism while surveying mechanisms that sustain long-lived plasma cells.

Kelvin P. Lee

Frontiers in Immunology · Review

MYCRead paper

Abstract excerpt from Kinase-independent PIM2 signaling controls MYC-driven transcriptional networks in multiple myeloma. Authors: Christopher Schorr; Daniela Petrusca; Joyce Hardwick; Alexander Kinstedt; Louise Carlson; Julia Grace Reinke; Kelvin Lee

2026Conference abstract

PIM2 controls MYC transcriptional networks

This meeting abstract examines kinase-independent PIM2–MYC regulation using chromatin profiling and gene-expression experiments in myeloma cells.

Daniela N. Petrusca · Kelvin P. Lee

IU Cancer Research Day · Poster 135

PIM2MYCRead abstract

Abstract excerpt from Targeting MYC signaling in lung neuroendocrine carcinomas with PIM2 and AURKA inhibition. Authors: Tianhao Zhou; Katherine Minton; Andrew Perfetti; Olivia Terry; Anthony Cuadros; Mateusz Opychal; Kelvin Lee; Misty Shields

2026Conference abstract

PIM2, AURKA and MYC in lung cancer

This meeting abstract evaluates JP11646 and alisertib in lung neuroendocrine cancer models and examines PIM2–MYC signaling and AURKA phosphorylation.

Kelvin P. Lee

IU Cancer Research Day · Poster 66

PIM2MYCRead abstract

20256 publications

Abstract excerpt from Novel Autoregulation of PIM2 Expression Sustains Plasma Cell Survival in Multiple Myeloma 2916. Authors: Christopher Schorr; Daniela Petrusca; Joyce Hardwick; Louise Carlson; Julia Grace Reinke; Kelvin P. Lee

20 Nov 2025Conference abstract

PIM2 autoregulation in myeloma

This conference abstract describes a kinase-independent PIM2 feedback mechanism involving MYC that helps sustain PIM2 expression in myeloma cells.

Daniela N. Petrusca · Kelvin P. Lee

The Journal of Immunology

PIM2MYCRead abstract

Abstract excerpt from PIM2 supports survival of multiple myeloma cells by modulating mitochondrial biogenesis 4075. Authors: Daniela Nicoleta Petrusca; Christopher Rolf Schorr; Louise Mari Carlson; Joyce Hardwick; Peter Lander; Scott Olejniczak; Kelvin P. Lee

20 Nov 2025Conference abstract

PIM2 and mitochondrial biogenesis

This conference abstract links kinase-independent PIM2 activity to mitochondrial biogenesis and MYC-associated metabolic programs in myeloma cells.

Daniela N. Petrusca · Kelvin P. Lee

The Journal of Immunology

PIM2MYCRead abstract

Abstract excerpt from MYC partners with kinase-independent PIM2 at key promoters in multiple myeloma. Authors: Christopher Schorr; Alexander Kinstedt; Daniela Petrusca; Louise Carlson; Joyce Hardwick; Julia Grace Reinke; Kelvin Lee

3 Nov 2025Conference abstract

MYC–PIM2 promoter regulation

This conference abstract reports PIM2 and MYC co-occupancy at the PIM2 and MRPS10 promoters, extending the proposed kinase-independent regulatory mechanism.

Daniela N. Petrusca · Kelvin P. Lee

Blood

PIM2MYCRead abstract

Abstract excerpt from PIM2-dependent modulation of mitochondrial mass and function in multiple myeloma. Authors: Daniela Petrusca; Christopher Schorr; Joyce Hardwick; Louise Carlson; Peter Lander; Julia Grace Reinke; Scott Olejniczak; Kelvin Lee

3 Nov 2025Conference abstract

PIM2-dependent mitochondrial function

This conference abstract reports that lowering PIM2 protein impairs mitochondrial mass and function and tests its kinase-independent survival role in myeloma models.

Daniela N. Petrusca · Kelvin P. Lee

Blood

PIM2MYCRead abstract

September 2025Conference abstract

The PIM2 transcriptional network

This conference abstract identifies a PIM2–MYC–SP1 transcriptional circuit and reports disruption of that circuit by JP11646.

Daniela N. Petrusca · Kelvin P. Lee

Clinical Lymphoma, Myeloma & Leukemia

PIM2MYCRead abstract

Abstract excerpt from Abstract 3037: Targeting pro-survival MYC oncogene expression in small cell lung cancer and large cell neuroendocrine carcinoma of the lung with a novel small molecule PIM2 inhibitor. Authors: Katherine G. Minton; Anthony H. Cuadros; Olivia C. Terry; Phu D. Pham; Mateusz Opyrchal; Kelvin P. Lee; Misty D. Shields

21 Apr 2025Conference abstract

Targeting MYC in lung neuroendocrine cancer

This conference abstract examines JP11646 in MYC-amplified lung neuroendocrine cancer models and proposes disruption of PIM2–MYC signaling.

Kelvin P. Lee

Cancer Research

PIM2MYCRead abstract

20244 publications

Abstract excerpt from Unraveling the Kinase-Independent Autoregulatory Mechanism of PIM2 in Multiple Myeloma. Authors: Christopher Rolf Schorr; Daniela Nicoleta Petrusca; Louise Carlson; Joyce Hardwick; Julia Grace Reinke; Kelvin P. Lee

5 Nov 2024Conference abstract

Kinase-independent PIM2 autoregulation

This conference abstract implicates MYC and SP1 in a kinase-independent feedback loop that sustains PIM2 expression in myeloma.

Daniela N. Petrusca · Kelvin P. Lee

Blood

PIM2MYCRead abstract

Abstract excerpt from P-280 Elucidating the Kinase-Independent Autoregulatory Loop of PIM2 in Multiple Myeloma. Authors: Christopher Schorr; Daniela Petrusca; Louise Carlson; Joyce Hardwick; Julia Grace Reinke; Kelvin Lee

September 2024Conference abstract

The PIM2 feedback loop

This conference abstract tests a kinase-independent PIM2 feedback loop involving MYC and reports reduced promoter activity after selective inhibition.

Daniela N. Petrusca · Kelvin P. Lee

Clinical Lymphoma Myeloma and Leukemia

PIM2MYCRead abstract

Abstract excerpt from Investigating the kinase-independent autoregulatory loop of PIM2 in multiple myeloma. Authors: Christopher Schorr; Daniela Petrusca; Louise Carlson; Joyce Hardwick; Julia Grace Reinke; Kelvin Lee

2024Conference abstract

Investigating the PIM2–MYC feedback loop

This meeting abstract reports promoter and chromatin experiments investigating a MYC-linked, kinase-independent PIM2 feedback mechanism.

Daniela N. Petrusca · Kelvin P. Lee

IU Cancer Research Day · Poster 51

PIM2MYCRead abstract

Abstract excerpt from JP11646-mediated PIM2 inhibition has potent antitumor effects in small cell lung cancer and large cell neuroendocrine carcinoma of the lung. Authors: Katherine Minton; Phu Pham; Mateusz Opyrchal; Kelvin Lee; Misty Shields

2024Conference abstract

PIM2 inhibition in lung cancer models

This meeting abstract evaluates JP11646 sensitivity and PIM2/MYC protein responses in small-cell lung cancer and large-cell neuroendocrine carcinoma models.

Kelvin P. Lee

IU Cancer Research Day · Poster 76

PIM2MYCRead abstract

20231 publications

Abstract excerpt from Targeting S1PR1 and p62-mediated signaling as a therapeutic approach to multiple myeloma bone disease. Authors: Daniela N. Petrusca; Silvia Marino; Attaya Suvannasankha; Judith Anderson; Evgeny Berdyshev; Kelvin P. Lee; G. David Roodman; Deborah L. Galson

2023Conference abstract

S1PR1, p62 and c-MYC signaling

This conference abstract tests ozanimod with a p62 inhibitor and reports lower GFI1 and c-MYC signaling alongside improved osteoblast differentiation.

Daniela N. Petrusca · Kelvin P. Lee

ASBMR Annual Meeting · JBMR supplement

MYCRead abstract

20223 publications

Abstract excerpt from Targeting PIM2 by JP11646 results in significant antitumor effects in solid tumors. Authors: Eriko Katsuta; Malgorzata Gil-Moore; Justine Moore; Mohamed Yousif; Alex A. Adjei; Yi Ding; Justin Caserta; Carmen M. Baldino; Kelvin P. Lee; Irwin H. Gelman; Kazuaki Takabe; Mateusz Opyrchal

3 Aug 2022Journal article

Targeting PIM2 in solid tumors

The study finds that JP11646 promotes PIM2 degradation and suppresses growth across several preclinical solid-tumor models.

Kelvin P. Lee

International Journal of Oncology

PIM2Read paper

Abstract excerpt from Role of Sphingolipids in Multiple Myeloma Progression, Drug Resistance, and Their Potential as Therapeutic Targets. Authors: Daniela N Petrusca; Kelvin P Lee; Deborah L Galson

8 Jun 2022Journal article

Sphingolipids, MYC and myeloma survival

This review examines sphingolipid signaling in myeloma, including the GFI1–SGPP1–S1P pathway and its role in c-MYC protein stability.

Daniela N. Petrusca · Kelvin P. Lee

Frontiers in Oncology · Review

MYCRead paper

Original abstract from GFI1-Dependent Repression of SGPP1 Increases Multiple Myeloma Cell Survival. Authors: Daniela N. Petrusca; Patrick L. Mulcrone; David A. Macar; Ryan T. Bishop; Evgeny Berdyshev; Attaya Suvannasankha; Judith L. Anderson; Quanhong Sun; Philip E. Auron; Deborah L. Galson; G. David Roodman

2 Feb 2022Journal article

GFI1, sphingolipids and c-MYC stability

The study links GFI1 repression of SGPP1 to increased sphingosine-1-phosphate and stabilization of c-MYC, supporting myeloma-cell survival.

Daniela N. Petrusca

Cancers

MYCRead paper

20212 publications

Abstract excerpt from MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages. Authors: Seyeon Bae; Peter Sang Uk Park; Yeji Lee; Se Hwan Mun; Eugenia Giannopoulou; Takayuki Fujii; Kelvin P. Lee; Sara Nunes Violante; Justin R. Cross; Kyung-Hyun Park-Min

15 Jun 2021Journal article

MYC links glycolysis and inflammation

The study shows that MYC-driven early glycolysis influences inflammatory macrophage responses through lactate metabolism and IRF4 regulation.

Kelvin P. Lee

Cell Reports

MYCRead paper

Abstract excerpt from Game of Bones: How Myeloma Manipulates Its Microenvironment. Authors: Tyler Moser-Katz; Nisha S Joseph; Madhav V Dhodapkar; Kelvin P Lee; Lawrence H Boise

9 Feb 2021Journal article

MYC and the myeloma microenvironment

This review examines myeloma–microenvironment interactions, including MYC dysregulation, translocations and signaling pathways that support tumor growth.

Kelvin P. Lee

Frontiers in Oncology · Review

MYCRead paper

20182 publications

Abstract excerpt from Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis. Authors: Daniela N Petrusca; Denise Toscani; Feng-Ming Wang; Cheolkyu Park; Colin D Crean; Judith L Anderson; Silvia Marino; Khalid S Mohammad; Dan Zhou; Rebecca Silbermann; Quanhong Sun; Noriyoshi Kurihara; Deborah L Galson; Nicola Giuliani; G David Roodman

4 Oct 2018Journal article

GFI1, c-MYC and myeloma bone disease

The study links GFI1 to myeloma growth, survival and bone destruction, with experiments measuring changes in c-MYC protein expression.

Daniela N. Petrusca

Journal of Hematology & Oncology

MYCRead paper

Abstract excerpt from Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma. Authors: Anna Bianchi-Smiraglia; Archis Bagati; Emily E. Fink; Hayley C. Affronti; Brittany C. Lipchick; Sudha Moparthy; Mark D. Long; Spencer R. Rosario; Shivana M. Lightman; Kalyana Moparthy; David W. Wolff; Dong Hyun Yun; Zhannan Han; Anthony Polechetti; Matthew V. Roll; Ilya I. Gitlin; Katerina I. Leonova; Aryn M. Rowsam; Eugene S. Kandel; Andrei V. Gudkov; P. Leif Bergsagel; Kelvin P. Lee; Dominic J. Smiraglia; Mikhail A. Nikiforov

10 Sep 2018Journal article

MYC-independent polyamine regulation

The study directly tests MYC binding sites and MYC protein responses, finding that AHR regulation of ODC1 and polyamine production is MYC independent.

Kelvin P. Lee

The Journal of Clinical Investigation

MYCRead paper

20161 publications

Abstract excerpt from Novel inhibition of PIM2 kinase has significant anti-tumor efficacy in multiple myeloma. Authors: Jayakumar R. Nair; Justin Caserta; Krista Belko; Tyger Howell; Gerald Fetterley; Carmen Baldino; Kelvin P. Lee

23 Dec 2016Journal article

Novel PIM2 inhibition in myeloma

The study reports that JP11646 inhibits PIM2 activity and expression and reduces tumor burden in preclinical myeloma models.

Kelvin P. Lee

Leukemia

PIM2Read paper

20151 publications

1 May 2015Conference abstract

PIM2 in plasma-cell survival

This conference abstract examines PIM2 inhibition across IL-6, dendritic-cell and CD28 survival pathways in myeloma models.

Kelvin P. Lee

The Journal of Immunology

PIM2Read abstract

20142 publications

Abstract excerpt from Targeting the Serine-Threonine Kinase PIM2: Implications in IL-6 Mediated Survival in Myeloma. Authors: Jayakumar R Nair; Tyger L Howell; Justin Caserta; Carmen M Baldino; Gerald Fetterly; Kelvin P Lee

6 Dec 2014Conference abstract

PIM2 and IL-6 survival signaling

This conference abstract studies IL-6-driven PIM2 signaling and reports that JP11646 counteracts microenvironment-mediated myeloma-cell protection.

Kelvin P. Lee

Blood

PIM2Read abstract

Abstract excerpt from The Tao of myeloma. Authors: Lawrence H. Boise; Jonathan L. Kaufman; Nizar J. Bahlis; Sagar Lonial; Kelvin P. Lee

5 Aug 2014Journal article

MYC within the biology of myeloma

This review relates plasma-cell identity and cancer genetics, including MYC translocations and IRF4–MYC regulation, to the activity of myeloma therapies.

Kelvin P. Lee

Blood · Review

MYCRead paper

20131 publications

Abstract excerpt from Overcoming CD28-Mediated Multi-Drug Resistance With a Novel PIM2 Inhibitor. Authors: Carmen M. Baldino; Jayakumar R. Nair; Justin Caserta; Megan Murray; Stephane Dumas; Yvonne Flanders; Kelvin P. Lee

15 Nov 2013Conference abstract

PIM2 inhibition and drug resistance

This conference abstract reports that JP11646 disrupts CD28-mediated protection from cell death in preclinical myeloma models.

Kelvin P. Lee

Blood

PIM2Read abstract

20101 publications

Abstract excerpt from Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemias. Authors: Hima Bansal; Sanjay Bansal; Manjeet Rao; Kevin P Foley; Jim Sang; David A Proia; Ronald K Blackman; Weiwen Ying; James Barsoum; Maria R Baer; Kevin Kelly; Ronan Swords; Gail E Tomlinson; Minoo Battiwalla; Francis J Giles; Kelvin P Lee; Swaminathan Padmanabhan

22 Jul 2010Journal article

HSP90, WT1 and c-MYC in leukemia

The study reports that HSP90 inhibition destabilizes WT1 and lowers downstream c-MYC and BCL-2 protein expression in myeloid leukemia models.

Kelvin P. Lee

Blood

MYCRead paper

The research The possibilities

20263 publications

Plasma-cell longevity and MYC metabolism

PIM2 controls MYC transcriptional networks

PIM2, AURKA and MYC in lung cancer

20256 publications

PIM2 autoregulation in myeloma

PIM2 and mitochondrial biogenesis

MYC–PIM2 promoter regulation

PIM2-dependent mitochondrial function

The PIM2 transcriptional network

Targeting MYC in lung neuroendocrine cancer

20244 publications

Kinase-independent PIM2 autoregulation

The PIM2 feedback loop

Investigating the PIM2–MYC feedback loop

PIM2 inhibition in lung cancer models

20231 publications

S1PR1, p62 and c-MYC signaling

20223 publications

Targeting PIM2 in solid tumors

Sphingolipids, MYC and myeloma survival

GFI1, sphingolipids and c-MYC stability

20212 publications

MYC links glycolysis and inflammation

MYC and the myeloma microenvironment

20182 publications

GFI1, c-MYC and myeloma bone disease

MYC-independent polyamine regulation

20161 publications

Novel PIM2 inhibition in myeloma

20151 publications

PIM2 in plasma-cell survival

20142 publications

PIM2 and IL-6 survival signaling

MYC within the biology of myeloma

20131 publications

PIM2 inhibition and drug resistance

20101 publications

HSP90, WT1 and c-MYC in leukemia

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